Citation

Swann AC. Neuropsychiatry (London) 2011; 1(6): 599-610.

Copyright

(Copyright © 2011, Future Medicine)

DOI

10.2217/npy.11.69

PMID

unavailable

Abstract

Antisocial personality disorder (ASPD) and bipolar disorder are both characterized by impulsive behavior, increased incarceration or arrest, addictive disorders and suicidal behavior. These characteristics appear more severe in the combined disorders. Individuals with ASPD who also have bipolar disorder have higher rates of addictive disorders and suicidal behavior and are more impulsive, as measured by questionnaires or behavioral laboratory tests. Those with bipolar disorder who have ASPD have higher rates of addictive, criminal and suicidal behavior, earlier onset of bipolar disorder with a more recurrent and predominately manic course and increased laboratory-measured, but not questionnaire-rated, impulsivity. These characteristics may result in part from differential impulsivity mechanisms in the two disorders, with bipolar disorder driven more by excessive catecholamine sensitivity and ASPD by deficient serotonergic function. © 2011 Future Medicine Ltd.

Language: en

Keywords

human; bipolar disorder; aggression; suicide attempt; suicidal behavior; comorbidity; disease severity; risk factor; review; substance abuse; disease association; priority journal; behavior therapy; impulsiveness; criminal behavior; disease course; recurrent disease; nonhuman; serotoninergic system; bipolar I disorder; hypomania; mental instability; psychopathy; sociopathy; heredity; catecholamine; postsynaptic receptor