Citation

Fisekovic S, Celik D, Loga-Zec S. HealthMed 2011; 5(6): 1821-1828.

Copyright

(Copyright © 2011, DRUNPP)

DOI

unavailable

PMID

unavailable

Abstract

INTRODUCTION: The risk of suicide and other causes of premature death are high in patients with chronic psychotic disorders. Approximately 50% of patients with schizophrenia and schizoaffective disorder attempt suicide, and around 10% patients with schizophrenia commit suicide. Aims: The aim of this study was to describe the anti-suicide effects of clozapine in treatment of schizophrenia and schizoaffective disorder.

MATERIALS AND METHODS: The clinical longitudinal and prospective study included 41 patients who attempted suicide and who accepted treatment with clozapine at the Department of Psychiatry of the University Clinical Centre of Sarajevo. Patients were assessed at baseline and after 4, 8, 12, 16, 20 and 24 weeks using the BPRS, the GAF and the CGI scale.

RESULTS: A statistically significant improvement was found for BPRS total score (χ2(6) = 232.127; P <.001), GAF total score (χ2(6) = 221.370; P <.001) and CGI score (χ2(6) = 230.569; P <.001).

CONCLUSION: The usage of clozapine in patients with schizophrenia and schizoaffective disorder at high risk for suicide is associated with significant reduction in suicidal behavior and personality disorder.

Language: en

Keywords

Suicide attempts; Schizophrenia; Clozapine; Schizoaffective disorder; Hostile behavior