Citation

Kornstein SG, Young EA, Harvey AT, Wisniewski SR, Barkin JL, Thase ME, Trivedi MH, Nierenberg AA, Rush AJ. Menopause 2010; 17(4): 828-839.

Copyright

(Copyright © 2010, Lippincott Williams and Wilkins)

DOI

10.1097/gme.0b013e3181d770a8

PMID

unavailable

Abstract

OBJECTIVE: The purpose of this study was to determine whether there are differences in depression characteristics among premenopausal, perimenopausal, and postmenopausal women with major depressive disorder. This study also evaluated these differences between postmenopausal women with major depressive disorder who are taking and not taking hormone therapy.

METHODS: Analyses conducted with data from the Sequenced Treatment Alternatives to Relieve Depression study focused on female outpatients with nonpsychotic major depressive disorder seeking treatment in 41 primary or psychiatric care settings across the United States. Baseline demographic and clinical characteristics were compared among women not taking hormone therapy who were premenopausal (n = 950), perimenopausal (n = 380), or postmenopausal (n = 562). These comparisons were also made between postmenopausal women (n = 768) taking (n = 171) or not taking (n = 562) hormone therapy.

RESULTS: After adjusting for sociodemographic and clinical baseline differences, premenopausal women were more likely to present with irritability than were either perimenopausal or postmenopausal women and were more likely to have decreased appetite and less likely to have early-morning insomnia than were perimenopausal women. Postmenopausal women were more likely to have suicidal ideation and poorer physical functioning than were either of the other groups and were more likely to have sympathetic arousal and gastrointestinal symptoms than were premenopausal women. After adjusting for baseline differences, postmenopausal women taking hormone therapy had better physical functioning, fewer melancholic features, less sympathetic arousal, and more lack of involvement in activities than did women not taking hormone therapy.

CONCLUSIONS: Menopause status and postmenopausal use of hormone therapy may influence the clinical presentation of major depressive episodes in women. © 2010 by The North American Menopause Society.

Language: en

Keywords

Humans; United States; Adult; Female; Middle Aged; adult; human; Severity of Illness Index; Health Status; Depression; suicide; Suicide; female; Prospective Studies; Gastrointestinal Diseases; insomnia; suicidal ideation; Arousal; anxiety; Major depressive disorder; physical activity; major depression; clinical trial; comorbidity; disease severity; psychology; progesterone; article; major clinical study; anorexia; Hormone therapy; pathophysiology; middle aged; gastrointestinal symptom; melancholia; appetite; health status; physiology; multicenter study; irritability; prospective study; hormonal therapy; menopause; estrogen; hormone substitution; premenopause; psychological rating scale; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders; Irritable Mood; arousal; menopausal syndrome; Menopause; Appetite; postmenopause; Hormone Replacement Therapy; severity of illness index; Postmenopause; sympathetic function