Citation

Üstündaǧ M, Güloğlu C, Orak M, Altunci YA, Doǧan H, Tamam Y. Anadolu Psikiyatri Derg. 2010; 11(2): 145-150.

Copyright

(Copyright © 2010, Cumhuriyet Universitesi, Publisher ScopeMed-GESDAV)

DOI

unavailable

PMID

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Abstract

OBJECTIVE: Since using of olanzapine becomes widespread in the world, clinical features of olanzapine intoxication become important for emergency departments. In our study, we evaluated the patients with Olanzapine intoxication retrospectively.

METHODS: Olanzapine overdose patients who were admitted to an emergency department between February 2004 and April 2007 were included in the study. The Poisoning Severity Score of the European Association of Poison Centers and Clinical Toxicologists was used to assess intoxication severity.

RESULTS: In our study we include fifteen olanzapine overdose patients. Female and male ratio was two (10/5). The average age was 27.33±9.27 years (range: 17-48 years). The ingested olanzapine doses ranged from 50 to 600 mg whereas the mean of admission time was 3.96±2.38 (range: 1.5-10) hours after ingestion. For a subgroup of patients ingesting olanzapine alone, The Poisoning Severity Score was 'minor' in four (44.4%), 'moderate' in four (44.4%), and 'severe' in one (11.2%) patients. While minor intoxication symptoms occurred in a broad range of ingested doses (50-75 mg), moderate intoxications were observed at a minimal ingested reported dose of 140 mg. Finally 13 patients were discharged after full recovery and two patients died.

CONCLUSION: Our findings showed that olanzapine overdose is relatively well tolerated especially when it is not accompanied by any co-ingestant. However, it can be life threaten when it is high doses are ingested or in association with other ingestants. There is correlation between dose and clinical features or prognosis.

Language: tr

Keywords

adolescent; adult; Intoxication; human; suicide; Suicide; female; male; Emergency department; disease severity; drug overdose; Olanzapine; article; clinical article; clinical feature; emergency ward; olanzapine; Clinic feature