Citation

Lakhal K, Pallancher S, Mathieu-Daude JC, Harry P, Capdevila X. Int. J. Clin. Pharmacol. Ther. 2010; 48(1): 79-83.

Copyright

(Copyright © 2010, Dustri-Verlag)

DOI

10.5414/CPP48079

PMID

unavailable

Abstract

BACKGROUND: Bromazepam intoxication is very common but surprisingly rarely reported. Case description: We describe the case of a 73-year-old woman who suffered from a prolonged coma after acute self poisoning with bromazepam (serum concentration of 2,000 ng/ml at admission, 2 - 10 hours after ingestion of up to 180 mg) and zolpidem (900 ng/ml at admission). Only the former lasted at toxic concentrations. Recovery of consciousness allowed extubation on Day 16. Repeat-dose activated charcoal (25 g every 6 h from Day 14 to 16) resulted in minimal effects on bromazepam grossly estimated kinetics.

CONCLUSION: Despite its relativel low theoretic half-life, bromazepam may induce a prolonged life-threatening coma, even in the absence of renal or hepatic failure. © 2010 Dustri-Verlag Dr. K. Feistle.

Language: en

Keywords

human; Suicide; female; aged; case report; fentanyl; drug overdose; Attempted; article; drug intoxication; liquid chromatography; mass spectrometry; coma; neurotoxicity; activated carbon; cerebrovascular accident; amiodarone; flumazenil; hypertension; zolpidem; amnesia; diabetes mellitus; atorvastatin; bromazepam; Glasgow coma scale; insulin; aspiration pneumonia; suxamethonium; toxicity testing; heparin; essential hypertension; metronidazole; QRS complex; Charcoal; unconsciousness; amlodipine; sinus bradycardia; PR interval; heart atrium fibrillation; cefotaxime; ramipril; creatinine clearance; etomidate; esomeprazole; gliclazide; bradypnea; betahistine; Drug-drug interaction; fluindione; dipyridamole; Time factors; Anti-anxiety agents/poisoning; Bromazepam/poisoning; CYP2C19; Cytochrome; Esomeprazole; Intestinal dialysis; Zolpidem/poisoning