Citation

Chen CY, Tzeng NS, Chen YC. Gen. Hosp. Psychiatry 2010; 32(6): 647.e7-647.e9.

Copyright

(Copyright © 2010, Elsevier Publishing)

DOI

10.1016/j.genhosppsych.2010.07.001

PMID

unavailable

Abstract

Growing evidence suggests that proinflammatory responses will be a crucial issue for developing neuropsychiatric disorders. Recent clinical trials demonstrated that adjunctive therapy of cyclo-oxygenase (COX)-2 inhibitor was effective for major depression. Here, we present the case of an elderly depressed woman with acute cognitive deficit who was refractory to multiple antidepressants but only responsive to celecoxib, a COX-2 inhibitor, in acute treatment and sustaining remission for a 5-year treatment course. Our finding suggests that a therapeutic effect of celecoxib exists for major depressive disorder comorbid with neurocognitive dysfunction. © 2010 Elsevier Inc.

Language: en

Keywords

human; female; aged; case report; insomnia; Inflammation; suicide attempt; major depression; pain; Major depression; article; antidepressant agent; human cell; acute disease; amfebutamone; cognitive defect; sertraline; gastrointestinal symptom; trazodone; patient compliance; drug withdrawal; relapse; psychomotor retardation; maintenance therapy; diabetes mellitus; drug response; midazolam; remission; thought disorder; Remission; psychopathy; metformin; celecoxib; dizziness; patient assessment; drug induced headache; treatment duration; drug substitution; absence of side effects; pseudodementia; Celecoxib