Citation

Ramsdena CA, Rileyb PA. Arkivoc 2010; 2010(1): 260-274.

Copyright

(Copyright © 2010)

DOI

10.3998/ark.5550190.0011.107

PMID

unavailable

Abstract

Tyrosinase is a copper containing enzyme that oxidises both phenols and catechols to orthoquinones. The oxidation of catechols (oxidase activity) is associated with a gradual and irreversible inactivation of the enzyme. This suicide inactivation has been interpreted in terms of the enzyme occasionally oxidising catechols as phenols (oxygenase activity) leading to reductive elimination of copper. In this account experimental evidence supporting the authors' mechanism is reviewed and discussed. © ARKAT USA, Inc.

Language: en

Keywords

Tyrosinase; Suicide inactivation; Catechols; Reductive elimination; Oxidase; Oxygenase