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Citation |
Oruch R, Lund A, Pryme IF, Holmsen H. Journal of Chemical Biology 2010; 3(2): 67-88. |
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Copyright |
(Copyright © 2010) |
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DOI |
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PMID |
unavailable |
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Abstract |
Patients respond differently to psychotropic drugs, and this is currently a controversial theme among psychiatrists. The effects of 16 psychotropics on cell membrane parameters have been reported. These drugs belong to three major groups used in therapeutic psychiatry: antipsychotics, antidepressants, and anxiolytic/hypnotics. Human platelets, lacking dopamine (D2) receptors (proposed targets of most psychotropics), have been used as a cell model. Here we discuss the effects of these drugs on three metabolic phenomena and also results from Langmuir experiments. Diazepam, in contrast to the remaining drugs, had negligible effects on metabolic phenomena and had no effects in Langmuir experiments. Psychotropic drugs may work through intercalation in membrane phospholipids. It is possible that the fluidity of membranes, rich in essential fatty acids, the content being influenced by diet, could be a contributing factor to the action of psychotropics. This might in turn explain the observed major differences in therapeutic response among patients. © 2010 Springer-Verlag. Language: en |
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Keywords |
human; depression; stroke; schizophrenia; diet; suicide attempt; review; antidepressant agent; anxiolytic agent; neuroleptic agent; lipid metabolism; monoamine oxidase inhibitor; serotonin uptake inhibitor; tricyclic antidepressant agent; priority journal; Cholesterol; anxiety disorder; drug mechanism; electroconvulsive therapy; seizure; tardive dyskinesia; weight gain; agranulocytosis; akathisia; drug effect; side effect; enzyme substrate; dystonia; parkinsonism; brain function; non insulin dependent diabetes mellitus; electrocardiography; Psychotropic drugs; heredity; unspecified side effect; neuroleptic malignant syndrome; lipid composition; phospholipid; SPECT; essential fatty acid; disorders of mitochondrial functions; NSAIDs; MLC; cell membrane; turnover time; Human platelets; Langmuir Blodgett film; membrane fluidity; PET. fMRI; PLA 2; PPI cycle; PUFAs; Solid-stateNMR |