Citation

Mattoo S, Shah R, Rajagopal R, Biswas P, Singh S. Indian J. Psychiatry 2009; 51(2): 139-140.

Copyright

(Copyright © 2009, Medknow Publications)

DOI

10.4103/0019-5545.49456

PMID

unavailable

Abstract

Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases.

Language: en

Keywords

adult; human; female; case report; Overdose; Schizophrenia; anger; Psychosis; suicide attempt; emergency care; treatment outcome; drug overdose; article; clinical feature; quetiapine; disease course; stomach lavage; drowsiness; electroconvulsive therapy; delusion; hostility; drug safety; patient compliance; risperidone; lorazepam; irritability; paranoid schizophrenia; chlorpromazine; side effect; agitation; medical examination; clonazepam; Deliberate self harm; reinforcement; psychosocial withdrawal; electrocardiography; mini mental state examination; Quetiapine; biochemistry; disease duration; ST segment depression; thorax radiography; auditory hallucination; agitated depression; plastic surgery; supraventricular tachycardia; persecutory delusion; drug dose increase; nerve injury; tablet formulation; ECG abnormality; median nerve