Citation

Haussleiter IS, Brüne M, Juckel G. Ther. Adv. Neurol. Disorders 2009; 2(1): 13-29.

Copyright

(Copyright © 2009)

DOI

10.1177/1756285608100325

PMID

unavailable

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system. Demyelinization of nerve fibres not only affects the motor and sensory systems functionally, but may also cause psychopathological signs and symptoms. In addition to the psychiatric manifestations of MS, many patients have reactive psychological problems that are often hard to distinguish from the 'organic' causation of psychopathology. In any event, psychiatric comorbidity in MS deserves greater clinical attention than has been previously paid, because the presence of psychopathology may have deleterious effects on the disease process and impair coping with disability. © 2009, SAGE Publications. All rights reserved.

Language: en

Keywords

human; suicide; dementia; bipolar disorder; psychotherapy; depression; prevalence; Coping; Multiple sclerosis; psychosis; clinical trial; comorbidity; clozapine; Psychiatric comorbidity; dextromethorphan; review; fatigue; Outcome; mental disease; disease association; amitriptyline; clinical feature; cognitive defect; desipramine; fluoxetine; mirtazapine; monoamine oxidase inhibitor; noradrenalin uptake inhibitor; serotonin uptake inhibitor; sertraline; priority journal; headache; cognitive therapy; disease course; anxiety disorder; lithium carbonate; coping behavior; electroconvulsive therapy; placebo; risperidone; alpha interferon; fever; unindexed drug; mania; quinidine; flu like syndrome; myalgia; levodopa; etiracetam; modafinil; methylprednisolone; multiple sclerosis; amantadine; pemoline; malaise; aripiprazole; euphoria; beta interferon; unspecified side effect; beta1a interferon; glatiramer; cyclophosphamide; interleukin 1; pathological crying; pathological laughter; donepezil; 4 aminopyridine; pseudobulbar palsy