Citation

Leithead JA, Simpson KJ, MacGilchrist AJ. Eur. J. Gastroenterol. Hepatol. 2009; 21(2): 230-232.

Copyright

(Copyright © 2009, Lippincott Williams and Wilkins)

DOI

10.1097/MEG.0b013e32830dffd0

PMID

unavailable

Abstract

Hepatotoxicity associated with the therapeutic ingestion of the vitamin A metabolite acitretin is well recognized. No reported cases of hepatic dysfunction as a consequence of acitretin overdose are, however, present. Here for the first time we report a case of fulminant hepatic failure following an intentional overdose of 600 mg of acitretin. The patient fulfilled the King's College Hospital poor prognostic criteria by 66 h after overdose, but demonstrated a rapid improvement thereafter and did not require liver transplantation. Given the known association between psoriasis and depression, and the possible association of acitretin with psychiatric illness, this is an important potential adverse event. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Language: en

Keywords

Humans; Adult; Female; adult; human; female; Drug Overdose; prognosis; Suicide, Attempted; case report; Overdose; liver failure; depression; suicide attempt; disease severity; Psoriasis; drug overdose; psychology; Adverse effects; article; clinical feature; priority journal; albumin; anamnesis; blood level; hepatitis; psoriasis; alanine aminotransferase; creatine kinase; acetylcysteine; hepatic encephalopathy; laboratory test; gamma glutamyltransferase; etretin; kidney dysfunction; Acitretin; prothrombin time; chemically induced; Keratolytic Agents; keratolytic agent; Liver Failure, Acute; alkaline phosphatase; Acute liver failure; acute liver failure