Citation

Furuse T, Hashimoto K. Ann. Gen. Psychiatry 2009; 8.

Copyright

(Copyright © 2009, Holtzbrinck Springer Nature Publishing Group - BMC)

DOI

10.1186/1744-859X-8-26

PMID

unavailable

Abstract

BACKGROUND: Psychotic depression is a clinical subtype of major depressive disorder. A number of clinical studies have demonstrated the efficacy of the combination of an antidepressant (for example, a tricyclic antidepressant or selective serotonin reuptake inhibitor (SSRI)) and an atypical antipsychotic or electroconvulsive therapy in treating psychotic depression. In some cases, the clinician or patient may prefer to avoid antipsychotic drugs altogether because of the risk of extrapyramidal side effects (EPS) in patients with psychotic depression treated with these drugs.

METHODS: We report five cases where fluvoxamine monotherapy was effective in the patients with psychotic depression.

RESULTS: The scores on the Hamilton Depression (HAM-D) scale and the Brief Psychiatric Rating Scale (BPRS) in the five patients with psychotic depression were reduced after fluvoxamine monotherapy.

CONCLUSION: Doctors should consider fluvoxamine monotherapy as an alternative approach in treating psychotic depression because it avoids the risk of EPS from antipsychotic drugs. © 2009 Furuse and Hashimoto; licensee BioMed Central Ltd.

Language: en

Keywords

adult; human; female; male; aged; suicide attempt; Brief Psychiatric Rating Scale; article; clinical article; clinical feature; fluvoxamine; paranoia; sleep disorder; gastrointestinal symptom; delusion; Hamilton scale; flunitrazepam; depressive psychosis; drug response; etizolam; monotherapy; diagnostic and statistical manual of mental disorders; drug dose increase; clinical effectiveness; sigma 1 opiate receptor