Citation

Upthegrove R. Adv. Psychiatr. Treat. 2009; 15(5): 372-379.

Copyright

(Copyright © 2009, Royal College of Psychiatrists)

DOI

10.1192/apt.bp.108.005629

PMID

unavailable

Abstract

Depression in schizophrenia has been a neglected field for some time, but much evidence exists as to the common occurrence of affective disturbance in so-called non-affective psychosis. Depression is related to poor outcome in terms of functional recovery, relapse rate and suicide, and there is increasing evidence that it also precedes the onset of first-episode psychosis for many individuals. This article reviews recent steps forward in the evidence base for depression in schizophrenia in terms of prevalence, importance, assessment and treatment implications, with the aim of providing useful information for practising psychiatrists.

Language: en

Keywords

human; suicide; depression; prevalence; schizophrenia; psychosis; clozapine; risk factor; psychoeducation; review; antidepressant agent; neuroleptic agent; psychologic assessment; fluoxetine; cognitive therapy; disease course; family therapy; extrapyramidal symptom; Hamilton scale; akathisia; high risk patient; relapse; atypical antipsychotic agent; akinesia; convalescence; Beck Depression Inventory; psychological rating scale; outcome assessment; Positive and Negative Syndrome Scale; postpsychotic depression