Citation

Sorodoc L, Lionte C, Bologa C, Petris O, Sorodoc V, Buga C. Cent. Eur. J. Med. 2009; 4(4): 527-531.

Copyright

(Copyright © 2009)

DOI

10.2478/s11536-009-0057-y

PMID

unavailable

Abstract

The incidence of drug-induced pancreatitis is rare. There have been several reports of acute pancreatitis as a complication in acute poisoning with drugs or toxins. We present a case of a young woman with acute pancreatitis secondary to an overdose of nifedipine and acetaminophen in a suicide attempt. We excluded other causes of acute pancreatitis by clinical history, serum toxicology, serology, and abdominal imaging. The most likely underlying pathophysiological mechanism was ischemic injury of the pancreas secondary to severe collapse induced by nifedipine and possible acetaminophen-induced direct pancreatotoxicity. The pancreatitis resolved with treatment that included continuous veno-venous haemofiltration in an intensive care unit. Emergency and intensive care units should be aware of this unusual complication of such poisoning. To our knowledge, this is the first reported association between massive nifedipine overdose and acute pancreatitis. © 2009 Versita Warsaw and Springer-Verlag Berlin Heidelberg.

Language: en

Keywords

adult; human; female; Poisoning; case report; suicide attempt; Acetaminophen; drug overdose; article; drug intoxication; tachycardia; priority journal; stomach lavage; paracetamol; activated carbon; cyanosis; drug blood level; intensive care; nausea; hypotension; tinnitus; acetylcysteine; hemofiltration; glucagon; Hemofiltration; heart palpitation; acute pancreatitis; oxygen therapy; Pancreatitis; tachypnea; calcium chloride; nifedipine; chest tightness; Nifedipine; loading drug dose; hypertensive factor; intestine sound