Citation

Al Mutairi D, Elbayer M, Al Enezi SA. J. Kuwait Med. Assoc. 2008; 40(3): 239-240.

Copyright

(Copyright © 2008, Kuwait Medical Association)

DOI

unavailable

PMID

unavailable

Abstract

Isoniazid (INH) overdose can be effectively treated, only if, suspected. Seizures and coma are due to INH unless proved otherwise in patients with access to the drug. Acute INH intoxication is characterized by a clinical triad consisting of metabolic acidosis resistant to treatment with sodium bicarbonate, seizure which may be fatal and refractory to standard anticonvulsant therapy, and coma. Pyridoxine is the specific antidote for INH overdose. We report a case of a 25-yr-old lady, who in a suicidal attempt ingested a toxic dose of INH resulting in status epilepticus and was successfully treated with pyridoxine (Vit B6).

Language: en

Keywords

adult; human; female; Seizures; case report; suicide attempt; disease severity; drug overdose; article; physical examination; stomach lavage; intensive care unit; diazepam; pH; isoniazid; pyridoxine; convulsion; seizure; hospital discharge; phenytoin; alanine aminotransferase; aspartate aminotransferase; metabolic acidosis; acid base balance; treatment response; liver enzyme; drug treatment failure; treatment duration; alanine aminotransferase blood level; aspartate aminotransferase blood level; Pyridoxine; recommended drug dose; collapse; arterial carbon dioxide tension; cervical lymphadenopathy; INH; oxygen mask; tuberculous lymphadenitis