Citation

Dhillon R, Rossi S, Herrine SK. Ther. Clin. Risk Manag. 2008; 4(4): 789-796.

Copyright

(Copyright © 2008, Dove Press)

DOI

unavailable

PMID

unavailable

Abstract

Coinfection with hepatitis C virus (HCV) and HIV is an increasingly recognized clinical dilemma, particularly since the advent of highly active antiretroviral therapy. Several studies of this population have demonstrated both more rapid progression of liver disease and poorer overall prognosis compared to HCV monoinfected patients. Consensus guidelines, based primarily on the results of 4 major randomized trials, recommend treatment with peginterferon and ribavirin for 48 weeks in coinfected patients. However, this current standard of care is associated with lower response rates to therapy than those seen in monoinfected patients. Important predictors of response include HCV genotype, pretreatment HCV RNA level, and presence of rapid virologic response (RVR) and early virologic response (EVR). Use of weight-based ribavirin dosing appears to be safe and enhances the likelihood of sustained virologic response (SVR). Adverse effects most commonly encountered are anemia and weight loss. Mitochondrial toxicity can occur in the setting of concomitant nucleoside reverse transcriptase inhibitor use, especially didanosine, abacavir, and zidovudine, and these should be discontinued before initiation of ribavirin therapy. Discontinuation of therapy should be considered in patients failing to demonstrate EVR, though ongoing trials are investigating a potential role for maintenance therapy in these patients. Peginterferon combined with weight-based ribavirin is appropriate and safe for treatment of HCV in HIV-HCV coinfected patients. This review summarizes the data supporting these recommendations. © 2008 Dove Medical Press Limited. All rights reserved.

Language: en

Keywords

human; suicide; depression; anger; clinical trial; review; fatigue; anorexia; weight reduction; Human immunodeficiency virus infection; drug safety; placebo; interferon; drug efficacy; drug withdrawal; hepatitis C; Hepatitis C; side effect; attention deficit disorder; anemia; arthralgia; myalgia; ribavirin; dose response; Human immunodeficiency virus; low drug dose; drug contraindication; mental instability; hemolytic anemia; didanosine; zidovudine; drug fever; antiviral activity; peginterferon alpha2a; peginterferon alpha2b; liver fibrosis; virus resistance; drug dose reduction; genotype; virus load; highly active antiretroviral therapy; drug induced headache; Ribavirin; treatment duration; Peginterferon; erythropoietin; optimal drug dose; Human immunodeficiency virus infected patient; lassitude; drug dose escalation; antiviral therapy; mixed infection; virion