Citation

Argente Villaplana CR, Andrés MC, Real Collado JT, Martínez-Hervás S, Ascaso Gimilio JF, Rodríguez RC. Endocrinologia y Nutricion 2008; 55(8): 372-375.

Copyright

(Copyright © 2008)

DOI

10.1016/S1575-0922(08)72799-2

PMID

unavailable

Abstract

Drugs such as cocaine and atypical antipsychotic agents, such as olanzapine, are sometimes related to hyperglycemia. Whereas cocaine raises plasma glucose through catecholamine release, atypical antipsychotic agents mainly increase appetite and induce weight gain and the development of metabolic syndrome. Moreover, the latter group of drugs also act independently from weight gain or adiposity, due to inhibition of beta pancreatic cells and reduction of peripheral insulin action. We present the case of a 29-year-old non-diabetic woman with severe acute hyperglycemia in the context of a suicide attempt through intake of olanzapine and cocaine. After discontinuation of olanzapine and cocaine consumption, glycemia was immediately normalized without subsequent diagnosis of diabetes.

Language: es

Keywords

adult; human; female; resuscitation; case report; suicide attempt; Cocaine; Olanzapine; cocaine; article; clinical feature; olanzapine; drug withdrawal; anamnesis; glucose blood level; glucose; hyperglycemia; Atypical antipsychotic; Hyperglycemia; schizotypal personality disorder