Citation

Limosin F, Samuelian JC, Rouillon F. Journal of Aging and Pharmacotherapy 2007; 13(2): 7-19.

Copyright

(Copyright © 2007)

DOI

10.1300/J397v13n02_02

PMID

unavailable

Abstract

The efficacy and tolerance of paroxetine versus clomipramine were compared in 91 hospitalised subjects aged more than 60 years for whom major depression had been diagnosed. During treatment, their scores on the Hamilton Depression Scale and Montgomery-Asberg Depression Rating Scale dropped markedly compared to their scores at inclusion, without any significant differences being found at 3, 6 or 9 weeks between the condition of patients taking paroxetine and those taking clomipramine. As regards tolerance, there was significant difference between the groups for anticholinergic effects which were fewer in the paroxetine group (p = 0.038). Overall, the patients in this group experienced fewer side effects than those in the clomipramine group, and the smaller number of severe side effects in the paroxetine group caused fewer patients in this group to drop out of the study and led to less frequent attribution of side effects to drug action. Paroxetine, therefore, proved as effective as clomipramine in treating major depression in the elderly, and was somewhat better tolerated. Copyright © by The Haworth Press, Inc. All rights reserved.

Language: en

Keywords

human; Depression; female; male; aged; Elderly; insomnia; suicide attempt; major depression; clinical trial; treatment outcome; head and neck cancer; article; major clinical study; controlled study; clomipramine; paroxetine; syncope; xerostomia; controlled clinical trial; double blind procedure; hallucination; constipation; temazepam; confusion; hospital patient; drug tolerability; nausea; tremor; drug withdrawal; Hamilton scale; multicenter study; sweating; disease exacerbation; delirium; side effect; agitation; anticholinergic effect; nausea and vomiting; Hospitalisation; Paroxetine; paresthesia; dizziness; urinary tract infection; Montgomery Asberg Depression Rating Scale; drug dose increase; chloral hydrate; micturition disorder; Clomipramine; Serotonin selective reuptake inhibitors (SSRIs); urinary difficulty