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Abstract
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AIM: To observe the physical and mental symptoms, depression emotion and level of sex hormone in serum of women with climacteric syndrome (CS) of different traditional Chinese medicine (TCM) syndromes, and compare with healthy women.
METHODS: 1 Totally 154 climacteric women, who were inpatients or outpatients and aged 42-55 years, were selected from Puning Overseas Chinese Hospital from May 2003 to October 2005. And 39 healthy women who conducted health examinations in same hospital simultaneously were selected as control group, aged 41-59 years. They all participated in the study voluntarily to complete measuring scale and marker detection. 2 According to the standards for "climacteric syndrome" defined in the Diagnostics of Traditional Chinese Medicine which was applied in national senior medical colleges, the subjects were divided into 4 types of syndrome: liver-Qi stagnation (n=21), kidney-deficiency (KD, n=31), liver-Qi stagnation combined with KD (n=46) and inclusion of liver-Qi stagnation combined with KD and stasis (n=56). 3 Physical and mental symptoms of climacteric women were assessed with Common Physical and Mental Symptoms Scale, modified by Professor Peng Xie-ying, Xiangya Hospital of Central South University and included 14 items: worry, depression, paresthesia of skin, dizziness, impaired concentration, cool extremity, multidream and restless sleep, lumbago and backache, hypochondriasis, languor and debilitation, tinnitus, easy to excite, difficulty falling asleep and memory decrease. Each item was scored 0-2 points according to pathogenic degrees of none, mild and severe. 4 Depression emotion was evaluated with Hamilton Depression Rating Scale, consisted of somatization (psycho-anxiety, somatic anxiety, gastrointestinal tract symptom, hypochondriasis and insight); changes of body mass; cognitive handicap (guilty, suicide, agitation and intolerance);diurnal variation; retardation (depression emotion, work and interest retardation);sleep (difficulty falling asleep, superficial sleep and early awakening);feeling of despair (feeling of ability decrease, feeling of despair and feeling of inferiority). Most evaluations comprised 5 degrees (none, mild, moderate, severe and extremely severe) and scored 0-4 points, while part evaluations included 4 degrees (none, mild, moderate and severe) and scored 0-3 points. 5 Levels of estradiol (E2), testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH) in serum were determined with RIA. 6 Measurement data were compared with t test.
RESULTS: All the 154 CS women and 39 healthy women entered the analysis of results. 1 Comparison of Physical and Mental Symptoms Scale: The score of women with KD syndrome was lower than other 3 types (P < 0.05-0.01), and the scores of CS women were higher than those of control group (P < 0.05). 2 Comparison of Hamilton Depression Rating Scale: The scores of each item and total score in CS women were higher than control group (P < 0.05-0.01), and also higher in most women with KD syndrome than other 3 types (P < 0.05), except scores of diurnal variation and retardation in women with liver-Qi stagnation combined with KD and scores of cognitive handicap, diurnal variation and sleep disorder in women with inclusion of liver-Qi stagnation combined with KD and stasis. 3 Comparison of levels of sex hormone: FSH and LH in serum of women with liver-Qi stagnation syndrome were higher than that with KD syndrome (P < 0.05). E2 level was notably lower in women with inclusion of liver-Qi stagnation combined with KD and stasis than with KD syndrome (P < 0.05), but LH level was significantly increased (P < 0.05). T, FSH and LH levels of CS women were remarkably higher than those of control group (P < 0.05-0.01) while E2 level was remarkably lower (P < 0.05).
CONCLUSION: Physical and mental symptoms as well as depression emotion of CS women are more serious than in healthy women, with the abnormal sex hormone level in serum. The CS women with KD syndrome possess the lightest physical and mental symptoms as well as depression emotion, and most similar level of sex hormone with normal women.
Language: zh |