Citation

Kumar R, Singh B, Sharma SR, Singh N, Singh J. Med. Legal Update 2006; 6(2): 33-35.

Copyright

(Copyright © 2006, R.K. Sharma and Institute of Medico-Legal Publications)

DOI

unavailable

PMID

unavailable

Abstract

Paraphenylenediamine (PPD) poisoning has been known for many years. Accidental or deliberate ingestion of Paraphenylenediamine has rarely been reported, but is potentially severe. We report a case of systemic poisoning with paraphenylenediamine (PPD) presenting with characteristic features of severe angioneurotic edema, rhabdomyolysis and intravascular hemolysis with hemoglobinuria culminating in acute renal failure. There is no specific antidote available but some guidelines for management of such a case are reviewed which includes therapy with gastric lavage, IV fluid infusion, mechanical ventilation, alkalinization of urine, corticosteroids, vasopressors and renal replacement therapy.

Language: en

Keywords

adult; human; male; case report; suicide attempt; kidney failure; rhabdomyolysis; review; drug intoxication; clinical feature; unclassified drug; physical examination; stomach lavage; urinalysis; artificial ventilation; corticosteroid; angioneurotic edema; laboratory test; neurologic examination; hemolysis; renal replacement therapy; phenylenediamine derivative; hemoglobinuria; paraphenylenediamine