Citation

Gambi F, De Berardis D, Campanella D, Carano A, Sepede G, Salini G, Scorrano B, Spinella S, Conti CM, La Rovere R, Valchera A, Mancini E, Ceddia D, Marchionni L, Calcagni E, Cotellessa C, Salerno RM, Ferro FM. European Journal of Inflammation 2005; 3(3): 127-134.

Copyright

(Copyright © 2005)

DOI

10.1177/1721727X0500300304

PMID

unavailable

Abstract

The aim of this study was to retrospectively evaluate the role of C-reactive protein, total cholesterol and high-density lipoprotein cholesterol in patients suffering from Major Depression (MD). Data of C-reactive protein, total cholesterol (TC) and high-density lipoprotein cholesterol of 37 adult outpatients (17 men, 20 women) with a DSM-IV diagnosis of MD were analyzed. Depression was measured with the 17-item Hamilton Depression Rating Scale (HAM-D) and with the Beck Depression Inventory (BDI). Suicide risk was evaluated with the Scale of Suicide Ideation (SSI). Patients with a lifetime history of attempted suicide were categorized as having higher suicide risk. Higher suicide risk patients showed higher C-reactive protein levels and lower high-density lipoprotein cholesterol levels than lower suicide risk patients whereas total cholesterol levels were not statistically different. C-reactive protein positively correlated with BDI, HAM-D, SSI scores and with number of previous depressive episodes. High-density lipoprotein cholesterol correlated inversely with BDI, HAM-D and SSI scores, whereas, no significant correlations were found between Total Cholesterol and other variables including C-reactive protein. In linear regression models, C-reactive protein was predictor of more severe depression and increased suicide risk. Lower high-density lipoprotein cholesterol levels were significantly predictive of increased suicide risk. Copyright © by BIOLIFE, s.a.s.

Language: en

Keywords

adult; human; female; male; Suicide risk; suicide attempt; major depression; C reactive protein; disease severity; prediction; Major depression; outpatient; C-reactive protein; article; controlled study; retrospective study; clinical article; cholesterol; Hamilton scale; high risk patient; correlation analysis; linear regression analysis; protein blood level; Beck Depression Inventory; high density lipoprotein cholesterol; diagnostic and statistical manual of mental disorders; High-density lipoprotein; Total cholesterol