Citation

Wayne D, Madigan T. Addict. Disord. Their Treat. 2004; 3(2): 83-86.

Copyright

(Copyright © 2004, Lippincott Williams and Wilkins)

DOI

10.1097/00132576-200406000-00005

PMID

unavailable

Abstract

OBJECTIVE: To describe the successful use of quetiapine and gabapentin in a patient with treatment-resistant schizoaffective disorder and comorbid crack cocaine addiction. Case Report: This case report describes a 34-year-old man with a history of schizoaffective disorder, depression, and cocaine addiction. After numerous suicide attempts, repeated hospitalizations, and treatment with various conventional and atypical antipsychotics over a 10-year period, the patient showed dramatic improvement on a combination of quetiapine 800 mg/d and gabapentin 1200 mg/d. Over a 5-month period, his mood stabilized; he became less paranoid; he was able to cope better with his auditory hallucinations; and he had no cravings for crack cocaine. In addition, the concomitant administration of quetiapine and gabapentin in this patient caused no adverse events.

CONCLUSION: The concomitant use of quetiapine and gabapentin may have beneficial effects in patients with schizoaffective disorder and comorbid cocaine addiction refractory to other medications. Controlled clinical trials are needed to confirm these findings.

Language: en

Keywords

adult; human; male; case report; mood; clozapine; Gabapentin; article; neuroleptic agent; clinical feature; priority journal; quetiapine; coping behavior; haloperidol; trazodone; drug efficacy; olanzapine; risperidone; valproic acid; chlorpromazine; gabapentin; side effect; schizoaffective psychosis; Quetiapine; perphenazine; cocaine dependence; auditory hallucination; benzatropine; Cocaine abuse; fluphenazine; Schizoaffective disorder