Citation

Tang YM, Xing YG, Li JG, Ding YQ, Lei CL, Tang XP. Chinese Journal of Neurology 2004; 37(3): 228-230.

Copyright

(Copyright © 2004)

DOI

unavailable

PMID

unavailable

Abstract

OBJECTIVE: To investigate the clinical features of severe acute respiratory syndrome (SARS) with neuropsychiatric involement.

METHODS: The clinical data of 173 patients of SARS with neuropsychiatric involement were retrospectively reviewed.

RESULTS: (1) The incidence of neuropsychiatric involement of SARS is about 53.2%. The manifestations mostly consist of: headache 67.1% ,dizziness 28.9%, consciousness disorder 10.4%, mental disorder 4.6%, focal manifestations 0.6%, seizures 1.2%, affective disorder 30.6%, in which anxiety 20.2%, depression 6.4%, tendency of committing suicide 1.2%, phobia 7.5%. (2) The number of serious cases with neuropsychiatric involement were much more than those of slight cases, P <0.01. (3) Ophthalmoscopic examination was performed for four patients and showed that the outline of optic disc was blurred, and the retinal veins were congestive. (4) Pathological characteristics of 2 cases: edema of the perivascular tissue and vascular wall of the small veins accompanying with mononuclear cells and lymphocytes infiltration, neuron degeneration and demyelination distributing in the brain.

CONCLUSIONS: The manifestation of neuropsychiatric involement is variable, and is associated with the severity of SARS. The typical pathological change is edema, localized necrosis and neuron degeneration and demyelination.

Language: zh

Keywords

human; article; major clinical study; retrospective study; clinical feature; necrosis; edema; lymphocytic infiltration; neurologic disease; respiratory failure; severe acute respiratory syndrome; Coronavirus infections; demyelination; mononuclear cell; nerve cell degeneration; Neurotic disorders; ophthalmoscopy; optic disk anomaly; Pneumonia, viral; Respiratory insufficiency; retina vein