Citation

Kitzlerová E. Ceska Slov. Psychiatr. 2004; 100(6): 360-367.

Copyright

(Copyright © 2004, Ceska Lekarska Spolecnost Jana Evangelisty Purkyne)

DOI

unavailable

PMID

unavailable

Abstract

Depressive disorder and cardiovascular diseases have common pathophysiological mechanisms. They include both biological and behavioral mechanisms. The principal biological mechanisms are: the activation of hypothalamo-pitutio-adrenal axis with increased activation of sympathetic nervous system, decreased vagal tonus followed by decreased heart rate variability and the changes in thrombogenesis with increased thrombocytic agregability. These three mechanisms are followed by the cascade of other processes, which are interconnected with each other, they are mutually inseparable and cause the damage of cardiovascular system. These findings are important for clinical praxis. Patients who suffer nontreated depressive disorder have a higher risk of development of cardiovascular diseases than the depressive patients treated with antidepressants including the tricyclic ones, which have the potential risk of cardiotoxicity. Hopeful is using the SSRI antidepressants, which have the benign cardiovascular profile. The conclusion includes the necessity to establish the diagnosis of the depressive disorder and than to treat it to prevent the patient's suicide and also to decrease the risk of development of the cardiovascular diseases.

Language: cs

Keywords

human; suicide; Depressive disorder; depression; risk assessment; heart rate variability; article; behavior; serotonin uptake inhibitor; tricyclic antidepressant agent; neuropathology; cardiotoxicity; cardiovascular disease; high risk patient; hypothalamus hypophysis adrenal system; adrenergic system; thrombocyte aggregation; Cardiotoxicity; Cardiovascular diseases; cardiovascular risk; hypophysis adrenal system; Pathophysiological mechanisms; thrombogenesis; vagus tone