Citation

Terada T, Onuma T, Katoh M. Journal of the Japan Epilepsy Society 2004; 22(3): 186-194.

Copyright

(Copyright © 2004)

DOI

10.3805/jjes.22.186

PMID

unavailable

Abstract

Depression is a common occurrence among epileptic patients. Most interictal depressive disorder is called interictal dysphoric disorder (IDD) or dysthymic-like disorder of epilepsy (DLDE). It is characterized by a chronic dysthymic state in which symptoms tend to occur intermittently and intermixed with brief euphoric moods, explosive irritability, anxiety, and somatoform symptoms, and is often improved by antidepressants medications. There are few reports that epileptic patients with major depression need to receive hospital treatment because of severe depressive state or suicide idea. We report 3 epileptic cases diagnosed major depression, who have severe depressive state and suicide idea. Depressive state is drug resistance and many kinds of antidepressants need to be used at full dose to evaluate the effect. Seizures were induced with maprotiline and clomipramine. Other drug had no seizures induction.

Language: ja

Keywords

adult; human; Depression; male; Epilepsy; Treatment; depression; anxiety; major depression; suicidal behavior; Major depression; epilepsy; article; anticonvulsive agent; antidepressant agent; disease association; dysthymia; clinical article; amitriptyline; clomipramine; fluoxetine; fluvoxamine; imipramine; nortriptyline; paroxetine; serotonin uptake inhibitor; lithium carbonate; amoxapine; Antidepressant drugs; mianserin; seizure; trazodone; carbamazepine; irritability; maprotiline; valproic acid; phenytoin; sulpiride; drug dose regimen; euphoria