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Citation |
Turcant A, Cailleux A, Le Bouil A, Allain P, Harry P, Renault A. J. Anal. Toxicol. 2000; 24(3): 157-164. |
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Copyright |
(Copyright © 2000, Preston Publications) |
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DOI |
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PMID |
10774534 |
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Abstract |
A case of self poisoning with metobromuron, a urea derivative used as a herbicide, is reported. Severe methemoglobinemia observed at the admission (80%) disappeared only at day 11, and hemolysis appeared at day 4 and decreased slowly to day 12. Metobromuron was analyzed by liquid chromatography with diode-array detection. Initial plasma concentration and elimination half-life were 4.9 mg/L and 5 h, respectively. Several metabolites were also detected, and four of those were identified by liquid chromatography-electrospray mass spectrometry. Normetobromuron, bromophenylurea, and bromoacetanilide were detected in plasma, but only N-methyl bromophenylurea was detected in urine. Bromoacetanilide probably results from acetylation of the intermediate bromoaniline. Methemoglobinemia could result from metabolization of metobromuron to bromoaniline and bromoacetanilide. Language: en |
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Keywords |
Humans; Adult; Male; Suicide, Attempted; Half-Life; Acute Disease; Chromatography, High Pressure Liquid/*methods; Acetanilides/*analysis; Aniline Compounds/*analysis; Herbicides/pharmacokinetics/*poisoning; Mass Spectrometry; Methemoglobinemia/blood/*chemically induced/urine; Molecular Structure; Phenylurea Compounds/pharmacokinetics/*poisoning; Spectrophotometry, Ultraviolet |