Citation

Khan S, Osinowo T, Pary RJ. Mental Health Aspects of Developmental Disabilities 2002; 5(2): 46-52.

Copyright

(Copyright © 2002)

DOI

unavailable

PMID

unavailable

Abstract

The high prevalence of psychiatric disorders in individuals with mental retardation is fairly well established. Individuals with Down syndrome had been conceived in the past as happy and cheerful people and were thought not to suffer from Major Depressive Disorder. There is relatively limited data on the issue of Major Depressive Disorder and Down syndrome in the literature. However there is a growing body of evidence that individuals with Down syndrome do indeed suffer from Major Depressive Disorder. There is no neurobiological basis to suggest that Down syndrome and Major Depressive Disorder may be mutually exclusive. In this paper, we will review the current literature on Major Depressive Disorder in Individuals with Down syndrome and present updates on treatment.

Language: en

Keywords

alpha adrenergic receptor stimulating agent; Alzheimer disease; amitriptyline; anorexia nervosa; anticonvulsive agent; antidepressant agent; autonomic dysfunction; behavior therapy; Bipolar disorder; carbamazepine; clinical feature; cognitive therapy; comorbidity; dementia; depression; Depression; desipramine; diagnostic accuracy; differential diagnosis; disease association; Down syndrome; ECT; electroconvulsive therapy; evidence based medicine; group therapy; hallucination; high risk population; human; hypothyroidism; lithium carbonate; long term care; macroglobulin; manic depressive psychosis; medical literature; mental deficiency; mental disease; neurobiology; neurologic disease; neuropsychological test; patient attitude; practice guideline; prevalence; prognosis; psychosis; quality of life; review; serotonin; serotonin agonist; serotonin blood level; serotonin uptake inhibitor; SSRI; suicide; Suicide; symptomatology; thyroid hormone; tricyclic antidepressant agent; valproic acid