Citation

Heerlein A. J. Neuroeuropsychiatry (Santiago, Chile) 2002; 40(Suppl 1): 21-45.

Copyright

(Copyright © 2002, Society of Neurology, Neurosurgery and Psychiatry, Chile)

DOI

unavailable

PMID

unavailable

Abstract

Introducction. Major Depressive Disorder is a serious medical condition that affect more than 8% of the population over their lifetimes. Recent years have seen considerable progress in the treatment of these disorders. This article reviews the current body of evidence for the pharmacologic treatment of major depression.

METHODS. We undertook a literature review.

RESULTS. Numerous studies have demonstrated a clear and effective role for antidepressants in the treatment of major depression. Pharmacologic investigations of other pathological conditions have identified several promising effects. There is also support for the efficacy of different or combined medication in atypical or resistant depression.

CONCLUSION. Continued research efforts are necessary, particularly regarding the short and long-term effects of therapy, the combination with psychotherapy and the development of new pharmacologic strategies. © 2006 Sociedad de Neurolog Psiquiatry Neurocirugbr.

Language: es

Keywords

agitation; agranulocytosis; akathisia; albuminuria; allergic reaction; alopecia; amfebutamone; amitriptyline; amoxapine; anorexia; anorgasmia; anticonvulsive agent; antidepressant agent; antihypertensive agent; arteritis; asthenia; cisapride; clonidine; congestive heart failure; constipation; convulsion; diarrhea; doxepin; drug activity; drug efficacy; duloxetine; dystonia; eosinophilia; epigastric pain; extrapyramidal symptom; face edema; fatigue; galactorrhea; gastrointestinal symptom; gingivitis; glaucoma; glucosuria; gynecomastia; heart arrhythmia; heart disease; heart infarction; hematuria; hepatitis; human; hypercholesterolemia; hyperlipidemia; hyperpyrexia; hypertension; hypertrichosis; hyperuricemia; hypocalcemia; insomnia; leukopenia; lidocaine; long term care; major depression; Major depression; medical research; menstrual irregularity; methylphenidate; migraine; milnacipran; mirtazapine; moclobemide; nausea; nefazodone; nortriptyline; orthostatic hypotension; parkinsonism; phenytoin; photosensitivity; pirlindole; pregabalin; propranolol; psoriasis; Psychopharmacology; psychosis; psychotherapy; QT prolongation; quinidine; rash; reboxetine; review; sedation; serotonin syndrome; serotonin uptake inhibitor; sexual dysfunction; side effect; somnolence; suicide; tachycardia; thrombocytopenia; Treatment; tricyclic antidepressant agent; trimipramine; urine retention; venlafaxine; vertigo; vomiting