Citation

Shimizu K, Shiono H, Matsubara K, Awaya T, Takahashi T, Saito O, Ogawa K, Mizukami H, Uezono T, Akutsu H. Leg. Med. (Elsevier) 2000; 2(2): 101-105.

Copyright

(Copyright © 2000, Japanese Society of Legal Medicine, Publisher Elsevier Publishing)

DOI

10.1016/S1344-6223(00)80032-2

PMID

unavailable

Abstract

A 78-year-old woman committed double suicide with a bolus injection of 1 g of lidocaine hydrochloride. The tissue distribution of lidocaine in this fatal poisoning was investigated using an improved gas chromatographic method. The blood level was 42 μg/ml and the brain concentration was 70 μg/g. Thus, the cause of death in this case was clearly diagnosed as lidocaine overdosing. The blood level of 42 μg/ml was higher than that calculated using the standard pharmacokinetic parameters. Lower blood/tissue ratios were also detected compared with the data described in the literature. These results indicated that the cardiac failure should have occurred immediately after the lidocaine injection. The present data show the distribution of lidocaine after acute death due to overdosing.

Language: en

Keywords

Acute death; aged; article; Autopsy; body fat; brain; case report; cause of death; comparative study; drug blood level; drug distribution; drug intoxication; drug overdose; female; heart; heart failure; human; human tissue; kidney; lidocaine; Lidocaine; liver; lung; Overdosing; Pharmacokinetics; spleen; suicide; tissue distribution; Tissue distribution