Citation

Coull MA, Lowther S, Katona CLE, Horton RW. Int. J. Neuropsychopharmacol. 2000; 3(2): 109-115.

Copyright

(Copyright © 2000, Cambridge University Press)

DOI

10.1017/S1461145700001851

PMID

unavailable

Abstract

Basal, neurotransmitter and G protein-mediated [3H]PI hydrolysis was measured in the frontal cortex, temporal cortex, hippocampus and thalamus from suicides, with a firm retrospective diagnosis of depression, and individually matched controls. Suicides were divided into those who had been free of antidepressant drugs for at least 3 months and those in whom prescription of antidepressants was clearly documented. There were no significant differences in basal, GTPγS-, 5-HT- or ACPD-stimulated [3H]PI hydrolysis in either antidepressant-free or antidepressant-treated suicides and their respective controls in the four brain regions studied. This was also the case when suicides were divided into those dying by violent or non- violent means. The two main conclusions from this study are: (i) neurotransmitter- (5-HT and ACPD) stimulated [3H]PI hydrolysis was unaltered in depression, and (ii) antidepressant treatment did not modify PI-mediated signal transduction.

Language: en

Keywords

1 amino 1,3 cyclopentanedicarboxylic acid; acetylsalicylic acid; amitriptyline; amoxapine; antidepressant agent; Antidepressant drugs; article; barbituric acid derivative; clinical article; clomipramine; controlled study; depression; Depression; dextropropoxyphene; diazepam; dosulepin; female; flupentixol; guanine nucleotide binding protein; haloperidol; human; human tissue; hydrolysis; imipramine; lithium; lofepramine; male; mianserin; neurotransmission; neurotransmitter; nitrazepam; paracetamol; phosphatidylinositol; Phosphatidylinositol hydrolysis; phosphoinositide metabolism; Post-mortem human brain; priority journal; procyclidine; serotonin; signal transduction; Signal transduction; suicide; Suicide; temazepam; thioridazine; tranylcypromine; trifluoperazine; trimipramine; violence