Citation

Healy D. Primary Care Psychiatry 2000; 6(1): 23-28.

Copyright

(Copyright © 2000)

DOI

10.1185/135525700543163

PMID

unavailable

Abstract

In the course of a randomised double-blind crossover study comparing the effects of reboxetine and sertraline in a group of healthy volunteers, two volunteers became suicidal on sertraline. This paper describes the characteristics of the reactions experienced by both subjects. These problems were associated with a combination of akathisia and disinhibition. Dysphoric or akathisic responses on their own to either drug did not lead to suicidality in this group of subjects. Copyright (C) 2000 by LibraPharm Limited.

Language: en

Keywords

akathisia; antidepressant agent; article; clinical trial; controlled clinical trial; controlled study; crossover procedure; double blind procedure; dysphoria; human; human experiment; normal human; primary medical care; priority journal; randomized controlled trial; reboxetine; Reboxetine; sertraline; Sertraline; suicidal behavior; Suicide