Citation

Hosak L, Tůma I, Hanus H. Ceska Slov. Psychiatr. 2000; 96(3): 126-130.

Copyright

(Copyright © 2000, Ceska Lekarska Spolecnost Jana Evangelisty Purkyne)

DOI

unavailable

PMID

unavailable

Abstract

D-fenfluramine releases serotonin from presynaptic parts of neurons and prevents its re-uptake. Serotonin causes an increase of prolactinaemia through hypothalamic serotonin receptors and a releasing factor. Thus the d- fenfluramine challenge test can be used as an indicator of a functional activity of the central serotonergic system. The main aim of the study was to compare the results of the d-fenfluramine test in depressed patients with a history of suicidal behaviour as against depressed patients without suicidal behaviour in the past as well as in responders versus nonresponders to amitriptyline, citalopram or fluoxetine. The test was performed in 48 hospitalized women at the average age of 41,2 years suffering from unipolar major depression before the treatment with amitriptyline or citalopram or fluoxetine. No significant differences were found between the study groups stated above in the average maximum increase of prolactinaemia during the test. D-fenfluramine challenge test is not useful as a marker of the previous suicidal behaviour in major depression as well as a predictor of the treatment response of major depression to amitriptyline, citalopram or fluoxetine according to our results.

Language: en

Keywords

adult; amitriptyline; article; citalopram; clinical article; clinical trial; D-fenfluramine test; depression; Depression; drug efficacy; drug mechanism; female; fenfluramine; fluoxetine; human; hyperprolactinemia; Prolactin; Response; serotonin; Serotonin; serotonin receptor; serotoninergic system; suicide; Suicide