Citation

Montagnon F, Saïd S, Payan C, Corruble E, Taleb M, Rouillon F. Ann. Med. Psychol. (Paris) 2000; 158(1): 11-20.

Copyright

(Copyright © 2000, Societe Medico-Psychologique, Publisher Elsevier Publishing)

DOI

unavailable

PMID

unavailable

Abstract

We conducted a prospective study in hospitalized patients in order to evaluate the prevalence and the clinical characteristics of patients resistant to antidepressant treatment. 151 patients, fulfilling DSM-III-R criteria for major depressive episode, were included in the study; sex ratio was two women for one man and mean age was 44 years. 34% had no previous major depressive episode, 58% had melancholic features and 34% had attempted suicide. Comorbidity was high: 57%, 51% and 54% had another current diagnoses on axis I, II and III respectively. 30% were not previously treated with antidepressant. 27% were considered as resistant to antidepressant treatment: these patients were more frequently female, had a higher education level and a more severe disease with longer duration of depressive episodes, more frequent psychiatric care, high frequency of melancholic features, fewer psychosocial stress and increased TSH compared with non-resistant patients.

Language: en

Keywords

adult; age distribution; aged; article; Clinical characteristics; clinical feature; comorbidity; controlled study; depression; disease severity; female; hospitalization; Hospitalization; human; major clinical study; male; mental stress; Resistant depression; sex ratio; thyrotropin; thyrotropin blood level