Citation

Alvarez JC, Spreux-Varoquaux O, Therond P. Sang Thrombose Vaisseaux 2000; 12(2): 83-88.

Copyright

(Copyright © 2000)

DOI

unavailable

PMID

unavailable

Abstract

A significant association between low or lowered cholesterol levels and violence is found in many studies: some metaanalyses of randomized trials found excess violent deaths in men receiving cholesterol-lowering therapy; observational cohort studies consistently showed increased violent death and violent behavior such as aggression or violent suicide attempt in persons with low cholesterol levels; experimental studies showed increased violent behavior in monkeys assigned to low-cholesterol diets. Several human and animal studies suggest a specific connection betweent low or lowered cholesterol levels and low or lowered serotonin activity, which in turn is casually linked to violent behavior. Thus, a connection between low cholesterol levels and increased violent behavior mediated by low brain serotonin activity is biologically plausible and has some experimental support which is evaluated in this review.

Language: en

Keywords

aggressiveness; antilipemic agent; cholesterol; cholesterol blood level; disease association; human; hydroxymethylglutaryl coenzyme A reductase inhibitor; hypocholesterolemia; neuropathology; nonhuman; serotonin; serotonin brain level; short survey; suicidal behavior; suicide; suicide attempt; violence