Citation

Lee SH, Lee JY, Park WS, Kim SY, Jang JJ, Yoo NJ. BJU Int. 1999; 83(6): 698-702.

Copyright

(Copyright © 1999, John Wiley and Sons)

DOI

10.1046/j.1464-410X.1999.00975.x

PMID

unavailable

Abstract

OBJECTIVE. To characterize the Fas-Fas ligand system, a main apoptotic pathway, in transitional cell carcinoma (TCC) of the urinary bladder, by analysing the expression of Fas and Fas ligand (FasL) in TCC samples.

MATERIALS AND METHODS. Archival paraffin-embedded tissues from 37 patients with TCC were analysed by immunohistochemistry to determine Fas and FasL expression.

RESULTS. Fas and FasL were detected on the cell surface and cytoplasm of respectively 34 (92%) and all cases analysed. The expression of Fas and FasL did not differ with the cytological grade of TCC.

CONCLUSION. The high expression of FasL in TCC, reported for the first time in the present study, suggests that FasL may contribute to the immune escape of TCC through killing Fas-bearing lymphocytes. Co-expression of Fas with FasL also suggests that TCC may have pathways resistant to Fas-mediated autocrine cell suicide.

Language: en

Keywords

antigen expression; Apoptosis; article; bladder carcinoma; cancer grading; cell killing; cell surface; clinical article; controlled study; cytoplasm; Fas; Fas ligand; human; human tissue; immunohistochemistry; Immunohistochemistry; lymphocyte; priority journal; transitional cell carcinoma; Transitional cell carcinoma