Citation

Viparelli U. Quaderni di Medicina e Chirurgia 1999; 15(1): 3-32.

Copyright

(Copyright © 1999)

DOI

unavailable

PMID

unavailable

Abstract

Since 20 years the author investigated a number of 'difficult pregnancies' for neuropsychic complications, which were either prexisting, relapsing or sharpened by pregnancy. In spite of some obstetricians perplexity, the use of wild anxiolytic, antidepressant, anticonvulsive or neuroleptic therapies, almost always under sonographic and monitoring control, provided no teratogenic effect. All of the 23 children, some of which to date become adult, showed in the further course of their infancy and adolescence a common peculiarity: a neuropsychobehavioural evolution as 'supernormal' subjects confirmed both by the parents evolution and by the psychologic profiles from educational and clinical observers. This contrasts with experimental animal models showing a 'neurobehavioural' involution after psychopharmacologic therapy during pregnancy. This topic must be their revised unless a 'reversed teratogenesis' is admitted. It is no more time for certain taboos (never psychopharmacologic therapy in pregnancy). The dramatic complications for the pregnant woman and the child (abortion, suicide, infanticide, etc.) deriving from the omission of such therapeutical intervention would be for more serious than the supposed drug-related teratogenic risks, which may only be ascribed to incongruous treatments.

Language: it

Keywords

adult; Alprazolam; Amitryptiline; anticonvulsive agent; antidepressant agent; anxiolytic agent; Benzodiazepine; echography; female; fetus; human; neuroleptic agent; newborn; obstetrics; Ontogenesis; patient monitoring; pregnancy complication; prenatal drug exposure; psychotropic agent; review; teratogenesis; Teratogenesis