Citation

Church NJ, Young DW. Journal of the Chemical Society - Perkin Transactions 1 1998; (9): 1475-1482.

Copyright

(Copyright © 1998)

DOI

10.1039/a800579f

PMID

unavailable

Abstract

Stereospecifically deuteriated samples of D-propargylglycine 1 have been prepared by reaction of the labelled Pmc-protected aziridine free acids 22 with a lithium acetylide followed by deprotection. These samples have been used to show that D-amino acid oxidase, in converting D-propargylglycine to the lactone 5, deprotonates C-3 in a non-stereospecific manner. This strongly supports the idea that non-enzymic deprotonation is a key step in the formation of this compound.

Language: en