Citation

Alesenko AV, Solov'ev AS, Terent'ev AA, Khrenov AV. Biology Bulletin 1998; 25(2): 116-124.

Copyright

(Copyright © 1998)

DOI

unavailable

PMID

unavailable

Abstract

Programed cell death, or apoptosis, is cell suicide. It develops according to a specific program, in which the sphingomyelin cycle products, ceramide, and sphingosine play the central role. This report, which provides published data and the authors' results, suggests that the content of ceramide and sphingosine in the cell is controlled by the tumor necrosis factor α and activators of Fas receptor. The results of many experiments confirmed that the products of the sphingomyelin cycle induce cell death according to an apoptotic type, and enhance induced apoptosis. Ceramide and sphingosine regulate the activity of enzymes involved in transduction of the apoptosis signal (protein kinases, Phosphatases, and proteases) and act as second messengers of the apoptosis signal. © 1998 MAK Hayka/Interperiodica Publishing.

Language: en