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Abstract
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OBJECTIVE: Determination of the genotype is critical in process of treatment and detection of cronic liver diease caused HIV infection. In this study, we examined blood samples of patients which have been sent to the Central Laboratory of çukurova University Medical Faculty Hospital for HCV genotyping and the distrubition and transmission routes of HCV genotypes in our region have been determined by examining patients file records.
METHODS: Between January 2015 and August 2016, HCV genotypes of 119 HCV-RNA (COBAS AmpliPrep / COBAS TaqMan HCV real-time PCR, Roche Diagnostics, Germany) the results of 119 patients who were identified as positive for HCV genotype were examined respectively from the record in Central Laboratory of çukurova University Medical Faculty Hospital. The demographic data of patients were obtained from the hospital electronic information system and patient files. "Sacace HCV Genotype Plus Real TM" kit was used for HCV genotyping which can detect genotype 1a, 1b, 2, 3, 4, 5a, 6 by real-time PCR method.
RESULTS: In the study of 119 patients, genotype 1 was detected in 71,4% (12.6% genotype 1a, 58.8% genotype 1b), genotype 3 in 16.8%, genotype 2 in 7.6%, genotype 4 in 3.4%. Genotype 5 (5a) (0.8%) which has not been reported previously in Adana, was determined in a Syrian female patient. 45.0% of patients who were infected with genotype 3 and 33.3% of patients with genotype 2 infection were intravenous drug users (IVDUs); and young men (83.3%) constituted the majority of this patient group. In addition, genotype 3 infection was detected in 4 patients who were have a risk for being IVDU with psychiatric disorders and suicide attempt. The distrubition of HCV genotypes in 11 Syrian patients nearly completed medical interventions was 63.6% genotype 1a, 27.3% genotype 4 and 9.1% genotype 5a respectively.
CONCLUSION: Epidemiology of HCV infection has varried in Turkey in recent years. Although medical interventions are the main risk factor and genotype 1b infection prevalence is 85-90% in our country, genotype 1b infection prevalence has been decreasing in recent years. The incidence of other genotypes are increasing, and previously undetected genotype 5 infection has been determined in Syrian immigrants in our country. Genotype 2 and genotype 3 infections which are associated with intravenous drug use have been increased in southern Turkey, such as Adana. Although transmission risk of HCV infection with medical interventions has decreased with increasing infection control measurement practice, the increasing number of IVDUs will be important in the HCV infection transmission in the future.
Language: tr |