Citation

Jafri MQ, Parhar A, Frank M, Nikiforov I. Cureus 2024; 16(4): e57850.

Copyright

(Copyright © 2024, Curēus)

DOI

10.7759/cureus.57850

PMID

38721171

PMCID

PMC11078534

Abstract

A 71-year-old male with a history of alcohol abuse and multiple suicide attempts was brought to the emergency department in an unconscious state. Initial assessment revealed profound obtundation and malnutrition. Laboratory findings demonstrated a significant anion gap metabolic acidosis with a high osmolar gap, suggestive of possible toxic alcohol ingestion. Despite negative serum alcohol levels, ethylene glycol poisoning was confirmed with a level of 226. Treatment included fluid resuscitation, bicarbonate therapy, and fomepizole administration. However, due to progressive multi-organ failure, continuous veno-venous hemodialysis was initiated. Despite interventions, the patient deteriorated rapidly, leading to a decision for hospice care, ultimately resulting in death. Ethylene glycol poisoning presents significant challenges in management, with potential complications including renal failure and multi-organ dysfunction. Fomepizole remains the cornerstone of treatment, but additional therapies such as ethanol administration were considered but ultimately deemed unnecessary due to associated risks. This case highlights the complexity and severity of ethylene glycol poisoning, emphasizing the need for early recognition and aggressive management strategies.

Language: en

Keywords

alcohol poisoning; ethanol; ethylene glycol; ethylene glycol poisoning; fomepizole; high anion gap metabolic acidosis; osmolar gap