Citation

Bown C, Wang JF, MacQueen G, Young LT. Neuropsychopharmacology 2000; 22(3): 327-332.

Copyright

(Copyright © 2000, Nature Publishing Group)

DOI

10.1016/S0893-133X(99)00091-3

PMID

10693161

Abstract

Regulation of ER stress proteins, such as the 78-kilodalton glucose regulated protein (GRP78) by chronic treatment with mood stabilizing drugs suggests that this family of proteins may be involved in the pathophysiology of mood disorders. Indeed, increased levels of GRP78, GRP94, and calreticulin, a third member of the ER stress protein family, were found in temporal cortex of subjects with major depressive disorder who died by suicide compared with controls and subjects who died by other means. No such differences were found in subjects with other psychiatric disorders such as bipolar disorder or schizophrenia. These data suggest a potential role for ER stress proteins in severe depression that merits further study.

Language: en

Keywords

*Heat-Shock Proteins; *Suicide; Adult; Calcium-Binding Proteins/analysis/*metabolism; Calreticulin; Carrier Proteins/analysis/*metabolism; Depressive Disorder/*metabolism/pathology; Endoplasmic Reticulum Chaperone BiP; Female; HSP70 Heat-Shock Proteins/analysis/*metabolism; Humans; Male; Membrane Proteins/analysis/*metabolism; Middle Aged; Molecular Chaperones/analysis/*metabolism; Ribonucleoproteins/analysis/*metabolism; Temporal Lobe/*metabolism/pathology