Citation

Kamijo Y, Soma K, Iwabuchi K, Ohwada T. Arch. Pathol. Lab. Med. 2000; 124(1): 127-129.

Copyright

(Copyright © 2000, College of American Pathologists)

DOI

10.5858/2000-124-0127-MNPLNF

PMID

10629144

Abstract

In a fatal occurrence of massive liver necrosis following ingestion of concentrated (90%) acetic acid, the patient showed evidence of hemolysis, disseminated intravascular coagulation, and liver dysfunction at only 45 minutes after exposure. With refractory to vigorous supportive care, the patient s condition deteriorated until death occurred 39 hours after ingestion, despite some improvement of coagulopathy. Autopsy revealed corrosive injuries in the upper gastrointestinal tract and massive hepatic necrosis in a periportal distribution without significant inflammation. A direct effect of the noxious agent on hepatocytes involving the portal circulation is suggested.

Language: en

Keywords

*Chemical and Drug Induced Liver Injury; Acetic Acid/*poisoning; Adult; Fatal Outcome; Female; Humans; Liver Diseases/pathology; Liver/*drug effects/pathology; Necrosis; Suicide