Citation

Chirokoff V, Pohl KM, Berthoz S, Fatseas M, Misdrahi D, Serre F, Auriacombe M, Pfefferbaum A, Sullivan EV, Chanraud S. Addict. Biol. 2024; 29(5): e13400.

Copyright

(Copyright © 2024, John Wiley and Sons)

DOI

10.1111/adb.13400

PMID

38706091

PMCID

PMC11070496

Abstract

Substance use disorders are characterized by inhibition deficits related to disrupted connectivity in white matter pathways, leading via interaction to difficulties in resisting substance use. By combining neuroimaging with smartphone-based ecological momentary assessment (EMA), we questioned how biomarkers moderate inhibition deficits to predict use. Thus, we aimed to assess white matter integrity interaction with everyday inhibition deficits and related resting-state network connectivity to identify multi-dimensional predictors of substance use. Thirty-eight patients treated for alcohol, cannabis or tobacco use disorder completed 1 week of EMA to report substance use five times and complete Stroop inhibition testing twice daily. Before EMA tracking, participants underwent resting state functional MRI and diffusion tensor imaging (DTI) scanning. Regression analyses were conducted between mean Stroop performances and whole-brain fractional anisotropy (FA) in white matter. Moderation testing was conducted between mean FA within significant clusters as moderator and the link between momentary Stroop performance and use as outcome. Predictions between FA and resting-state connectivity strength in known inhibition-related networks were assessed using mixed modelling. Higher FA values in the anterior corpus callosum and bilateral anterior corona radiata predicted higher mean Stroop performance during the EMA week and stronger functional connectivity in occipital-frontal-cerebellar regions. Integrity in these regions moderated the link between inhibitory control and substance use, whereby stronger inhibition was predictive of the lowest probability of use for the highest FA values. In conclusion, compromised white matter structural integrity in anterior brain systems appears to underlie impairment in inhibitory control functional networks and compromised ability to refrain from substance use.

Language: en

Keywords

*Diffusion Tensor Imaging; *Inhibition, Psychological; *Magnetic Resonance Imaging; *White Matter/diagnostic imaging/pathology; Adult; Alcoholism/physiopathology/diagnostic imaging; Anisotropy; Brain/diagnostic imaging/physiopathology; Corpus Callosum/diagnostic imaging/pathology; Ecological Momentary Assessment; EMA; Female; Humans; inhibition; Male; Marijuana Abuse/physiopathology/diagnostic imaging; Middle Aged; Neural Pathways/diagnostic imaging/physiopathology; resting state; Smartphone; Stroop; Stroop Test; Substance-Related Disorders/physiopathology/diagnostic imaging; SUD; Tobacco Use Disorder/physiopathology/diagnostic imaging; white matter; Young Adult