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Journal Article

Citation

Cheng B, Guo Y, Chen X, Lv B, Liao Y, Qu H, Hu X, Yang H, Meng Y, Deng W, Wang J. Psychoradiology 2022; 2(3): 121-128.

Copyright

(Copyright © 2022)

DOI

10.1093/psyrad/kkac015

PMID

38665602

PMCID

PMC10917173

Abstract

BACKGROUND: Although postpartum depression (PPD) and non-peripartum major depressive disorder (MDD) occurring within and outside the postpartum period share many clinical characteristics, whether PPD and MDD are the same or not remains controversial.

METHODS: The current study was devoted to identify the shared and different neural circuits between PPD and MDD by resting-state functional magnetic resonance imaging data from 77 participants (22 first-episodic drug-naïve MDD, 26 drug-naïve PPD, and 29 healthy controls (HC)).

RESULTS: Both the PPD and MDD groups exhibited higher fractional amplitude of low-frequency fluctuation (fALFF) in left temporal pole relative to the HC group; the MDD group showed specifically increased degree centrality in the right cerebellum while PPD showed specifically decreased fALFF in the left supplementary motor area and posterior middle temporal gyrus (pMTG_L), and specifically decreased functional connectivities between pMTG and precuneus and between left subgeneual anterior cingulate cortex (sgACC_L) and right sgACC. Moreover, sgACC and left thalamus showed abnormal regional homogeneity of functional activities between any pair of HC, MDD, and PPD.

CONCLUSIONS: These results provide initial evidence that PPD and MDD have common and distinct neural circuits, which may facilitate understanding the neurophysiological basis and precision treatment for PPD.


Language: en

Keywords

functional activity; functional connectivity; major depressive disorder; postpartum depression; resting-state fMRI

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