Citation

Alnefaie SA, Aldlgan AA, Albakiri KM, Kaabi MA, Alzwen GM, Al-Otaibi SS, Alasmari F. Saudi Pharm. J. 2024; 32(4): e102018.

Copyright

(Copyright © 2024, King Saud University, Saudi Pharmaceutical Society, Publisher Elsevier Publishing)

DOI

10.1016/j.jsps.2024.102018

PMID

38497087

PMCID

PMC10940806

Abstract

Outbreaks of methanol poisoning have been described in the medical literature worldwide. However, the few outbreaks that have occurred in Saudi Arabia remain undocumented. This is especially noteworthy in light of the fact that Saudi Arabia is among the countries that explicitly prohibit the usage of alcoholic beverages and recreational drugs. Herein, we describe five cases of methanol poisoning in Saudi Arabia. The first three comprise patients admitted to the emergency room (ER) with signs of methanol toxicity, such as heart palpitations, vomiting, and blurred vision; otherwise, those patients were considered medically free. The remaining two cases were examined postmortem. A headspace gas chromatography-flame ionization detector was used to test blood, vitreous humor, and urine samples for methanol. Specific lethal concentrations of methanol were defined based on published case studies as 23-740 mg/dL in blood and 12-396 mg/dL in vitreous humor. In postmortem cases of our present study, samples exhibited lethal concentrations: 118 and 257 mg/dL in blood, 116.3 and 283 mg/dL in vitreous humor. In ER cases, methanol concentrations in urine samples were lower, at 7.5, 9.1, and 20.9 mg/dL; however, toxic symptoms were still observed. These case studies indicate that it is necessary to raise community awareness about the risk of methanol poisoning in order to minimize future poisoning epidemics.

Language: en

Keywords

Blood; Ethanol; Methanol; Poisoning; Postmortem; Vitreous humour