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Abstract
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Datura is a genus of herbaceous plants of the nightshade family, also known as goldenrod, which is widely distributed worldwide [1], it is wild or cultivated all over the world, its flowers, leaves, stems, and seeds are all poisonous, especially seeds. Datura seeds are similar in appearance to pale ears and slightly sweetened (Figure 1), its main toxic components are hyoscyamine, scopolamine, atropine and other belladonna alkaloids. The toxin produces toxic effects by binding to muscarinic-like acetylcholine (Ach) receptors in the central and peripheral nervous systems. Studies have reported that children could be poisoned if they eat 3-8 seeds [2]. The clinical manifestations vary depending on the amount of intake and individual constitution, mild cases are only manifested as dry mouth, red face and red ears, increased heart rate, abdominal discomfort, etc [3], severe cases can die due to respiratory failure [4,5].
Cases of datura poisoning are clinically rare; in particular, cluster poisoning in children has rarely been reported or studied. Due to the difficulty of communicating with pediatric patients, and the poisoned patients are often present with neuropsychiatric symptoms, this makes history collection difficult and often leads to misdiagnosis. At the same time, compared with adults, pediatric patients have smaller poisoning doses, and the onset of poisoning is more urgent, the disease is more serious, the progression is faster, therefore, they need more timely medical treatment. From September 1 to 5, 2022, the Pediatric Intensive Care Unit (PICU) of the First Hospital of Lanzhou University, admitted 8 children with community mass datura poisoning, and some of them were in critical condition. Our study aims to improve the diagnosis and treatment of these children by analyzing the clinical features and prognosis of these children.
methods:%20Through%20retrospective%20investigation%20of%208%20children%20with%20datura%20poisoning%20in%20Lanzhou%20on%20September%201,%202022,%20we%20analyzed%20the%20history%20of%20clinical%20features,%20adjunctive%20examination,%20treatment,%20and%20follow-up.%0AResults%3A%20A%20total%20of%208%20children%20were%20enrolled%20in%20this%20study,%20including%202%20males%20(25%25)%20and%206%20females%20(75%25).%20The%20oldest%20was%209%20years%20old,%20the%20youngest%20was%207%20years%20old;%201%20case%20(12.5%25)%20with%20mild%20symptoms,%205%20cases%20(62.6%25)%20with%20ordinary%20symptoms,%20and%202%20cases%20with%20severe%20symptoms;%20in%20all%20cases,%20they%20had%20neurological%20impairment,%20shortness%20of%20breath,%20tachycardia%20and%20abdominal%20discomfort,%20and%20some%20children%20had%20clinical%20manifestations%20such%20as%20central%20fever%20and%20coma
Language: en |