Citation

El-Gharbawy DM, Kabbash IA, Ghonem MM. Toxicol. Res. (Camb.) 2023; 12(5): 873-883.

Copyright

(Copyright © 2023, RSC Publishing)

DOI

10.1093/toxres/tfad078

PMID

37915484

PMCID

PMC10615807

Abstract

BACKGROUND: Early identification of antipsychotic poisoned patients who may have a potential risk for intensive care unit (ICU) admission is crucial especially when resources are limited. Nomograms were previously used as a practical tool to predict prognosis and planning the treatment of some diseases including some poisoning conditions. However, they were not previously investigated in antipsychotic poisoning.

AIM: The current study aimed to construct a nomogram to predict the need for ICU admission in acute antipsychotic poisoning.

PATIENTS AND METHODS: This 2-year study included 140 patients acutely intoxicated with antipsychotics and admitted at Tanta University Poison Control Centre throughout July 2019 to June 2021. Personal and toxicological data, findings of clinical examination and electrocardiography, as well as, results of laboratory investigations at time of admission were recorded. According to the outcome, patients were divided into ICU-admitted and ICU-not admitted groups.

RESULTS: The results of this study provided a proposed nomogram that included five significant independent predictors for ICU admission in acute antipsychotic intoxications; the presence of seizures (OR: 31132.26[108.97-Inf]), corrected QT interval (OR: 1.04[1.01-1.09]), mean arterial blood pressure (OR: 0.83[0.70-0.92]), oxygen saturation (OR: 0.62[0.40 to 0.83)], and Glasgow Coma Scale (OR: 0.25 [0.06-0.56]).

CONCLUSION: It could be concluded that the developed nomogram is a promising tool for easy and rapid decision making to predict the need for ICU admission in acute antipsychotic poisoning.

Language: en

Keywords

Prediction; Prognosis; Acute poisoning; Antipsychotic medications; Intensive care unit admission; Nomogram