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Citation
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Jasny T, Kloka J, Old O, Piekarski F, Lotz G, Zacharowski K, Friedrichson B. Crit. Care 2023; 27(1): e409. |
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Abstract
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We express our gratitude to Romain Jouffroy and Benoît Vivien for their valuable commentary on our manuscript titled "Results from 237 extracorporeal membrane oxygenation runs with drowned patients: a nationwide retrospective study" [1, 2]. These colleagues suggest an analysis of drowned patients managed solely by cardiopulmonary resuscitation (CPR) alone versus those with the combination of CPR and extracorporeal membrane oxygenation (ECMO). Needless to say, that this approach can be an important and insightful sub-analysis of our data set.
The primary objective of our manuscript was to examine the variance among all hospitalized drowning cases, focusing on the comparison of outcomes between those treated with ECMO and those without. Pursuant to this objective, and in light of the sub-analysis proposed by Jouffroy et al., we examined all patients subjected to in-hospital (OPS 8-77*) and out-of-hospital (ICD U69.13!) CPR following drowning events between 2018 and 2020. Due to a change in coding for in-hospital resuscitation and out-of-hospital resuscitation, this short timeframe had to be selected. Using propensity score matching based on age and Elixhauser Score, each patient of the ECMO group was matched with a patient of the non-ECMO group with similar characteristics (Table 1), hence of 122 drowned patients 50% (n = 61) received CPR only and 50% (61) received CPR and ECMO [3]. Mortality was 86.9% (n = 53) for the ECMO group and 55.7% (n = 34) for the non-ECMO group. Logistic regression analysis showed a significant association of increased hospital mortality with V-A ECMO (OR 22.907, CI: 3.652-143.695) and a protective effect for hypertension (OR 0.086, CI: 0.013-0.59) (Fig. 1). Notably, this sub-analysis demonstrated a significantly elevated mortality in the ECMO group compared to the non-ECMO patients. Both groups, after propensity score matching, showed no significant difference in disease severity, measured via the Elixhauser Score (ECMO n = 13, IQR: 8-19; Non-ECMO n = 11, IQR: 5-20; p = 0.66). The potential differences that could have been revealed by clinically established scores, such as SOFA or SAPS II, remain a limitation of our data set...
Language: en |