Citation

Cohen T, Shomron N. Int. J. Mol. Sci. 2023; 24(16).

Copyright

(Copyright © 2023, Molecular Diversity Preservation International)

DOI

10.3390/ijms241612908

PMID

37629089

PMCID

PMC10454422

Abstract

Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.

Language: en

Keywords

PTSD; memory; microRNA; RNA; transcription