Citation

Naumenko Y, Yuryshinetz I, Zabenko Y, Pivneva T. Heliyon 2023; 9(7): e18342.

Copyright

(Copyright © 2023, Elsevier Publishing)

DOI

10.1016/j.heliyon.2023.e18342

PMID

37519712

PMCID

PMC10372741

Abstract

Traumatic brain injury (TBI) is defined as dysfunction or other evidence of brain pathology caused by external physical force. More than 69 million new cases of TBI are registered worldwide each year, 80% of them - mild TBI. Based on the physical mechanism of induced trauma, we can separate its pathophysiology into primary and secondary injuries. Many literature sources have confirmed that mechanically induced brain injury initiates ionic, metabolic, inflammatory, and neurovascular changes in the CNS, which can lead to acute, subacute, and chronic neurological consequences. Despite the global nature of the disease, its high heterogeneity, lack of a unified classification system, rapid fluctuation of epidemiological trends, and variability of long-term consequences significantly complicate research and the development of new therapeutic strategies. In this review paper, we systematize current knowledge of biomechanical and molecular mechanisms of mild TBI and provide general information on the classification and epidemiology of this complex disorder.

Language: en

Keywords

Mild traumatic brain injury; Acute injury; Excitotoxicity; Glial reactivity; Post-traumatic neurodegeneration; Subacute injury